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Indomethacin has been used to forestall cytokine storm – an irregular immune response that kills Covid-19 sufferers – in individuals with different well being situations. The drug prices Rs 5 a capsule, whereas Tocilizumab, a drug now used to deal with cytokine storm, prices Rs 60,000 per dose.
C hennai-based kidney transplant surgeon Dr Rajan Ravichandran, who used indomethacin on his transplant sufferers first in 1989 to forestall cytokine storms, wrote to ICMR and its counterparts within the US and the UK on April 29 suggesting a scientific trial. While the UK division of well being wrote again saying the proposal has been forwarded to its Therapeutic Taskforce, ICMR is but to behave on it.
I CMR director normal Dr Balram Bhargava advised TOI that the council has obtained about 185 such proposals. “ICMR, along with department of science and technology, department of biotechnology and the Council for Scientific and Industrial Research are looking into them one by one,” he mentioned.
I n the US, in the meantime, docs have discovered the drug to be efficient in some 60 Covid-19 sufferers, typically higher than hydroxycholorquine. Dr Jonathan Leibowitz, a main care doctor in Brooklyn, who used indomethacin on his sufferers in an e-mail to TOI , mentioned indomethacin “seems to have a clear positive effect and needs further investigation,” and indicated it was not being given the significance it deserve s.
Dr Ravichandran mentioned it might be used on Covid-19 sufferers as a repurpose drug, however a largescale scientific trial is crucial, given the affordability and the promising outcomes a number of research on the drug have proven.
Full report on www.toi.in