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GLP-1-based remedy of diabetes doesn’t trigger pancreatitis

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About 50,000 Danish diabetic sufferers are handled with GLP-1-based medicine. GLP-1 is a hormone that reduces the blood sugar and inhibits the urge for food, and it’s a frequent remedy for kind 2 diabetes and weight problems. A recognized facet impact of this specific remedy is that it will increase sufferers’ markers for pancreatitis.

Now, analysis from the Faculty of Health and Medical Sciences exhibits that the elevated markers will not be an indication of pancreatitis, however that the medicine is creating a brand new regular state, a so-called new regular state, within the sufferers. The new information can contribute to the protection of GLP-1-based medicines worldwide.

“The increased biomarkers should not be interpreted as a sign of disease. Our study shows that GLP-1 treatment makes the pancreatic cells ‘work’ a bit more than they usually do. Instead of running around the soccer field once, they do it twice. And that in itself is not dangerous. It is something you also see in other contexts,” explains Resident Medical Doctor and Assistant Professor Nicolai Albrechtsen from the Department of Biomedical Sciences and the Novo Nordisk Foundation Center for Protein Research on the Faculty of Health and Medical Sciences and Rigshospitalet.

New Steady State

Precisely as a result of GLP-1-based remedy is a really ceaselessly used remedy for diabetes and weight problems, there was worldwide deal with detecting and understanding harmful uncomfortable side effects—and thereby additionally on the elevated markers of pancreatitis.

Since 2012, in collaboration with Rigshospitalet and Hvidovre Hospital, the researchers have performed cell and animal research and now additionally a human trial, supporting that GLP-1-based remedy doesn’t improve pancreatitis, however reasonably will increase the exercise of the cells.

“We have recruited 17 overweight people who are suitable for receiving the maximum dose of GLP-1. Simultaneously with the treatment, we have monitored their possible development of pancreatitis by means of a particularly advanced imaging technique undertaken by Professor Andreas Kjær from the Department of Biomedical Sciences and Rigshospitalet. The patients did not develop inflammation, but their level of pancreatic enzymes, the biomarker of pancreatitis, increased. At the same time, we could see that the cell activity rose to a new normal level,” says Nicolai Albrechtsen.

In the examine, the take a look at topics had been examined by the use of blood samples and the particular imaging approach PET-MRI earlier than, throughout and after remedy with GLP-1. The PET-MR know-how gives a particular tracer that may present these cells within the physique which can be in a so-called energetic cell cycle. At the identical time, irritation in and across the cells might be seen.

The examine was performed by researchers from the Faculty of Health and Medical Sciences, Rigshospitalet and Hvidovre Hospital. The shut cooperation made it attainable for the analysis to maneuver from mice to people. This is the primary time that the potential mechanism between GLP-1-based remedy and elevated stage of pancreatic enzyme has been proven in people.

Study identifies indicators of acute pancreatitis not seen previous to COVID-19 pandemic

More data:
Maria S. Svane et al, No results of a six‐week intervention with glucagon‐like peptide‐1 receptor analogue on pancreatic quantity and edema in overweight males with out diabetes, Diabetes, Obesity and Metabolism (2020). DOI: 10.1111/dom.14106

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University of Copenhagen

GLP-1-based remedy of diabetes doesn’t trigger pancreatitis (2020, June 15)
retrieved 15 June 2020

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