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The IISc staff comprising Prof Kumaravel Somasundaram, Mainak Mondal and Ankita Lawarde of the division of microbiology and cell biology, has printed a scientific investigation into the doable origin and unfold of the virus in India in Current Science. The staff used genomics for his or her examine.
The researchers carried out systematic evaluation of genome sequences of virus isolates and inferred the doable supply of origin and important genetic variants of the viruses in India.
“The analysis revealed most (129 out of 137) Indian SARS-CoV-2 show more similarity to specific countries,” the article in Current Science reads. “In cluster A, Indian samples show more similarity to viruses found in Oceania, Kuwait and South Asian samples, while in cluster B, samples show more similarity to European, while there are a few numbers of Middle East/South Asian samples. These results indicate that the majority of Indian SARS-CoV-2 originated from Europe, Middle East, South Asia and Oceania regions.”
The remaining Indian isolates recognized with samples from China and East Asia. This signifies that these viruses might need been launched by Indian travellers from China and its neighbouring nations as they present shut resemblance to the “ancestral Chinese virus”.
“The probable source of origin of Indian SARS-CoV-2 viruses is countries from Europe and Oceania regions besides Middle East and South Asian regions,” the researchers stated. “The possible spread of the SARS-CoV-2 virus to India through Middle East countries from Europe and Oceania regions cannot be ruled out. Indeed, both A and B clusters contain samples from Middle East countries. In addition, these samples appear to split between I and G clades.”
In the absence of knowledge associated to journey/contact historical past of Indian sufferers, particular conclusions on the doable supply of the origin couldn’t be made. “Thus our result also indicates that there is a close connection between the source of the virus and countries that are most travelled by Indians,” they stated.
The examine additionally highlights the facility of speedy viral genome sequencing and public data- sharing to enhance the detection and administration of pandemic illnesses comparable to Covid-19. “It is important to point out that most countries in America, Europe, Oceania and East Asia were quick in supporting advanced scientific studies on the virus and disease process itself in suitable containment facilities with appropriate ethical clearance towards developing novel treatment modalities and preventive vaccines,” the researchers added.
The examine additionally emphasizes the significance of pathogen genomics by phylogenetic evaluation to find viral genetic range and perceive the viral transmission dynamics with eventual grasp on viral virulence and disease pathogenesis.