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“Covid-19 has almost brought normal life to a standstill in most parts of the world. With our research interest on repurposing known drugs/drug candidates targeting various diseases, we decided to analyse the available data on the deadly pathogen,” the workforce mentioned.
The workforce, comprising Prof Narayanaswamy Srinivasan (chief), Sohini Chakraborti and Sneha Bheemireddy, has recognized 29 potential repurpose-able brokers which are both accepted and/or investigational medicine.
This was achieved utilizing a easy in silico (carried out on pc) strategy based mostly on the precept of ‘neighbourhood behaviour’ in three-dimensional (3D) area and two-dimensional (2D) area of protein and small molecules respectively.
“Using this, we identified potential drugs/drug candidates which can be repurposed against protein targets encoded by the SARS-CoV-2 [the virus that causes Covid-19] genome,” the researchers mentioned. “And, based on our preliminary analysis, we have so far prioritized more than 20 known drugs/drug candidates which might elucidate anti-coronavirus properties by binding to the main protease of the pathogen.” The workforce additionally mentioned they’ve recognized 9 different investigational drug molecules.
These medicine belong to various therapeutic areas reminiscent of antiviral, anticancer, antibacterial brokers and so forth. Their analysis has been revealed on ChemRxiv, an open entry preprint archive for chemistry, and is but to be peer reviewed.
“The sole purpose of making these preliminary findings openly available to the community is for experimental biologists and biomedical researchers to investigate our predictions in experimental set ups and for clinicians to evaluate the potential of these findings for anti-Covid-19 treatment,” the researchers added.
Notably, other than many artificial molecules, their evaluation additionally hints that phytochemicals obtained from vinca plant (vinca alkaloids) and camptotheca tree (camptothecin and its derivatives) have the potential to bind to foremost protease of SARS-CoV-2.
“…In-depth investigation on our findings are currently on-going. Our findings should only be used for research purposes and we strongly urge that no individual should interpret these findings for any self-diagnosis or self-medication without the prior approval from competent international health/medical regulatory agencies,” the workforce mentioned.